Certain vaginal bacteria render HIV microbicide less effective
The results help to explain why this particular drug has had disappointing efficacy in women. Today, high HIV acquisition rates among women are a major global health concern. While the microbicide drug tenofovir routinely prevents the virus in men at great risk, efficacy of this drug in females has been variable. To explore a role for the microbiome in this variability, Nichole Klatt and colleagues used samples collected from a subset of participants in a clinical trial evaluating the effectiveness of tenofovir intravaginal gel in preventing HIV in South African women; unfortunately, during the study period, some of these women went on to contract the virus. Among the samples they analyzed, Klatt et al. identified two major vaginal bacterial compositions in women -- one dominated by the bacteria Lactobacillus , and the other, by Gardnerella vaginalis . Klatt et al. found that individuals where Lactobacillus predominated had around 3-fold greater protection ...